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20 Jan 2021

Each new analogue has affected one element or another of the effects of antihistamines but, in general terms, they all demonstrate the following characteristics: they are well absorbed from the gastrointestinal tract, they have local anesthetic effects, antagonize histamine with varying degrees of specificity, block histamine-induced contraction of smooth muscle, decrease secretions from lachrymal and salivary glands, have an atropine-like effect, tend to create sedation, dizziness and incoordination with varying degrees of intensity, sometimes hypersensitize individuals, especially evident as skin rashes and photosensitivity. Reports in the literature have suggested that antihistamines are contraindicated in asthma because they dry the secretions in the upper and lower respiratory tracts. Unquestionably, histamine is a cause of bronchospasm and hence a cause of asthma. Worse, antihistamines -- the standard treatment for itching and allergy -- often don't help. The less sedating antihistamines can be taken long term with no loss of efficacy, and an ongoing good safety profile. ABSTRACT: Histamine Is an Important mediator of asthma. Antihistamines have no role in the acute management of anaphylaxis. Their beneficial bronchoprotective and bronchodilator effects in asthma appear to be dose related2,4,7-13. Get the latest public health information from CDC: https://www.coronavirus.gov, Get the latest research information from NIH: https://www.nih.gov/coronavirus, Find NCBI SARS-CoV-2 literature, sequence, and clinical content: https://www.ncbi.nlm.nih.gov/sars-cov-2/. In fact, it was clear in the Anaphylaxis session at the Food Allergy Blogger’s Conference, that antihistamines are no long recommended for severe, life threatening allergic reactions. Please enable it to take advantage of the complete set of features! Reports in the literature have suggested that antihistamines are contraindicated in asthma because they dry the secretions in the upper and lower respiratory tracts. Antihistamines are usually safe for people who have asthma to use, but they can cause side effects. The protective effect of ketotifen in bronchial asthma. It is elevated in the airways of asthmatic patients and is responsible for many of the pathophysiological features in asthma. Copyright © 2021 Elsevier Inc. except certain content provided by third parties. Antihistamines often have anticholinergic activity, to which elderly patients are particularly sensitive. First-generation antihistamines are over-the-counter medications with mild sedative qualities. Some antihistamines can’t be taken with certain other medicines. 2006; 5(3):149-58 (ISSN: 1176-3450) Wilson AM. A lot, as it turns out. She once struggled with winter pollen, mistaking her symptoms with a common cold, but now takes daily antihistamines to them and reduce her chances of having an asthma attack. The association of viral and bacterial infections with exacerbations of wheezing in young asthmatic children. Asthma is linked with allergic rhinitis in terms of epidemiology, anatomy, physiology, immunopathology, and response to treatment14. Anticholinergic effects of antihistamines can trigger bronchospasm. If you have a lot of allergy symptoms, your doctor may use antihistamines to help provide relief, as well as get control of your asthma. pharmacists advise their asthmatic customers to avoid antihistamines and 75% of this group recommend avoidance because they believe antihistamines worsen asthmatic symptoms, despite the lack of sufficient clinical data to support this concern. Heat and water loss from the airways and exercise-induced asthma. 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