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20 Jan 2021

Losartan can cause mild or serious side effects. A class of drugs is a group of medications that work in a similar way. Changes in renal function including acute renal failure can be caused by drugs that inhibit the renin angiotensin system and by diuretics. Available for Android and iOS devices. When pregnancy is detected, discontinue Losartan as soon as possible. The usual starting and maintenance dose is 50 mg once daily for most patients. If you become pregnant, stop taking this medication right away and call your doctor. Oxidation of the 5-hydroxymethyl group on the imidazole ring results in the active metabolite of Losartan. Losartan potassium tablets USP, 50 mg … 50mg/12.5mg; 100mg/12.5mg; 100mg/25mg A prescription for this medication is refillable. If you want to stop taking losartan, talk with your doctor. Last updated on Aug 1, 2020. Injury or death of unborn babies. When pregnancy is detected, discontinue Losartan potassium as soon as possible. The lowest dose, corresponding to an average daily dose of 0.07 mg/kg, did not appear to offer consistent antihypertensive efficacy. Studies in rats indicate that Losartan crosses the blood-brain barrier poorly, if at all. Avoid use of aliskiren with Losartan potassium in patients with renal impairment (GFR <60 mL/min). Mean peak concentrations of Losartan and its active metabolite are reached in 1 hour and in 3 to 4 hours, respectively. The Components of Primary Endpoint (as a first event) counts only the events that define the primary endpoint, while the Secondary Endpoints count all first events of a particular type, whether or not they were preceded by a different type of event. Lower blood pressure also reduces your risk of kidney damage. In the subgroup of Black patients (n=533, 6% of the LIFE study patients), there were 29 primary endpoints among 263 patients on atenolol (11%, 26 per 1000 patient-years) and 46 primary endpoints among 270 patients (17%, 42 per 1000 patient-years) on Losartan potassium. In the Reduction of Endpoints in NIDDM with the Angiotensin II Receptor Antagonist Losartan (RENAAL) study involving 1513 patients treated with Losartan potassium or placebo, the overall incidences of reported adverse events were similar for the two groups. Other ARBs include olmesartan, valsartan, and telmisartan. Dosage Forms & Strengths. Advise patients receiving Losartan potassium not to use potassium supplements or salt substitutes containing potassium without consulting their healthcare provider [see Drug Interactions (7.1)]. Relative risk reduction from blood pressure reduction is similar across populations with varying absolute risk, so the absolute benefit is greater in patients who are at higher risk independent of their hypertension (for example, patients with diabetes or hyperlipidemia), and such patients would be expected to benefit from more aggressive treatment to a lower blood pressure goal. If they’re more severe or don’t go away, talk to your doctor or pharmacist. The following less common adverse reactions have been reported: Blood and lymphatic system disorders: Anemia. Cardiac disorders: Palpitations, syncope, atrial fibrillation, CVA. The table shows the number of events for each component in two different ways. Control of high blood pressure should be part of comprehensive cardiovascular risk management, including, as appropriate, lipid control, diabetes management, antithrombotic therapy, smoking cessation, exercise, and limited sodium intake. Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to estimate their frequency reliably or to establish a causal relationship to drug exposure: General Disorders and Administration Site Conditions: Malaise. What is the most important information I should know about Losartan potassium tablets? Significant levels of Losartan and its active metabolite were shown to be present in rat fetal plasma during late gestation and in rat milk. Children in the lowest dose group were given Losartan in a suspension formulation [see Dosage and Administration (2.1)]. This is the most serious warning from the Food and Drug Administration (FDA). Patients were randomized to receive once daily Losartan potassium 50 mg or atenolol 50 mg. Although the LIFE study favored Losartan potassium over atenolol with respect to the primary endpoint (p=0.021), this result is from a single study and, therefore, is less compelling than the difference between Losartan potassium and placebo. As a result, a normal adult dosage may cause levels of this drug to be higher than normal in your body. The more common side effects that can occur with losartan include: These effects may go away within a few days or a couple of weeks. This list does not contain all drugs that may interact with losartan. Be sure to avoid doing this when the weather is very hot or very cold. These studies demonstrate that the incidence of cough associated with Losartan therapy, in a population that all had cough associated with ACE-inhibitor therapy, is similar to that associated with hydrochlorothiazide or placebo therapy. Losartan potassium tablets may be administered with other antihypertensive agents. If you’re a senior, you may need a lower dosage, or a different dosing schedule. Also tell them about any vitamins, herbs, and supplements you use. Some antihypertensive drugs have smaller blood pressure effects (as monotherapy) in Black patients, and many antihypertensive drugs have additional approved indications and effects (e.g., on angina, heart failure, or diabetic kidney disease). Doses above 1.4 mg per kg (or in excess of 100 mg) daily have not been studied in pediatric patients [see Clinical Pharmacology (12.3), Clinical Studies (14.1), and Warnings and Precautions (5.2)]. For the primary endpoint and stroke, the effects of Losartan potassium in patient subgroups defined by age, gender, race and presence or absence of isolated systolic hypertension (ISH), diabetes, and history of cardiovascular disease (CVD) are shown in Figure 3 below. The pharmacodynamic consequences of concomitant use of Losartan and inhibitors of P450 2C9 have not been examined. 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